Study on the disinfection effect of slightly acidic hypochlorous acid water on the surface of objects in neonatal ward

Slightly Acidic Hypochlorous Acid Water (SAHW) is a kind of disinfectant generated by electrolysis of sodium chloride or hydrochloric acid solution, and its main component is hypochlorous acid (HClO), with a pH range of 5.0-6.5 and an effective chlorine concentration of 10-80 mg/kg. its name varies slightly among different standards, such as “slightly acidic electrolytic water”, “weakly acidic hypochlorous acid water”, etc., but the core characteristics are the same. Its name is slightly different in different standards, such as “slightly acidic electrolyzed water”, “weakly acidic hypochlorite water”, etc., but the core characteristics are the same:

Molecular structure: Hypochlorous acid (HClO) is a neutral small molecule with strong penetrating power, which can quickly enter the interior of microorganisms to destroy their structure.

Bactericidal mechanism: destroys bacterial cell membrane, viral proteins and nucleic acids through oxidizing effect, the bactericidal ability is 80 times of hypochlorite (ClO-).

Safety: Oral non-toxic, non-irritant, in line with FDA food additive standards, suitable for human contact scenarios.

National Standard Requirements for Disinfection of Object Surfaces in Neonatal Wards

According to the Technical Code for Disinfection in Medical Institutions and Hospital Disinfection Hygiene Standards, the neonatal ward is a high-risk area, and the total number of bacterial colonies on the surface of objects should be ≤5 CFU/cm².

Specific requirements include:

Disinfection frequency: clean and disinfect at least twice a day, and deal with contamination at any time.

Disinfectant selection: Recommended use of chlorine-containing disinfectants (e.g., effective chlorine concentration of 400-700 mg/L) or quaternary ammonium salt disinfectants (1000-2000 mg/L).

Special restrictions: The use of disinfectants is prohibited on the inside surfaces of the neonatal incubator, and only water cleaning is allowed.

Disinfection effect and mechanism of micro-acid water

1. Sterilization effect

Broad-spectrum: the killing rate of common pathogens such as Staphylococcus aureus, Escherichia coli and Candida albicans is ≥99.99%, and it is also effective against viruses (such as Norovirus and Influenza virus) and bacilli (such as Bacillus subtilis).

Persistence: Research shows that its disinfection effect is better than traditional chlorine disinfectant (such as 84 disinfectant) within 60 minutes, and the bacterial killing rate can reach more than 72%.

2. Mechanism of action

Chemical oxidation: hypochlorite molecules penetrate microbial cell membranes, oxidize proteins, nucleic acids and enzyme systems, leading to the death of pathogens.

Physical destruction: high oxidation potential changes the cell membrane potential and destroys the permeability of the lipid membrane, which is a physical sterilization process and is not easy to trigger drug resistance.

Comparative analysis with traditional disinfectants

Research Support:

Disinfectant wipes (with hypochlorite) had significantly lower bacterial counts (2.61 CFU/cm²) than chlorine-containing disinfectants (4.08 CFU/cm²) in the neonatal ward after 60 minutes.

Microacidic hypochlorite water had comparable MRSA clearance to chlorine-based disinfectants, but was safer.

Safety studies

Toxicological verification: It is confirmed to be non-toxic and non-irritating by acute oral toxicity, skin irritation and mutagenicity tests.

Clinical application: In surgical incision disinfection, the infection rate of using slightly acidic hypochlorite water (5%) is significantly lower than that of traditional disinfectants (25%).

Environmental friendliness: The decomposition products are water, oxygen and trace amount of sodium chloride, no environmental residue.

BLUEWAV---Professional medical grade hypochlorite generator manufacturer suggests that the following information should be referred to for neonatal ward application

Concentration selection: Recommended effective chlorine concentration of 20 ~ 80 mg / L, to avoid the potential impact of high concentrations on neonatal skin or equipment.

Frequency of use: routine disinfection 2 times a day, high-frequency contact areas (such as door handles, instrument surfaces) can be increased to 3 to 4 times.

Synergistic Measures:

Combine with microfiber wipes to enhance cleaning efficiency.

Avoid mixing with quaternary ammonium disinfectants to prevent neutralization of ingredients.

Future prospects of BLUEWAV

Stability Advantage: Our equipment produces a shelf life of up to two years under light-proof, sealed storage conditions of hypochlorite water.

Concentration advantage: 500ppm, 2000ppm, 15,000ppm

pH advantage: 3-7 adjustable

Operation advantage: one person touch screen/remote control, automated management

Installation advantage: plug and play, no complicated procedures

Consumption advantage: lower raw material consumption and power consumption than hypochlorite equipment appearing on the market, bringing you the convenience of low cost and high profit.

Conclusion.

Microacidic hypochlorite water shows significant advantages in the disinfection of object surfaces in neonatal wards by virtue of its broad-spectrum bactericidal and safe non-residual properties. It meets the national hygiene standard (≤5 CFU/cm²) and has a reliable effect on the removal of multidrug-resistant bacteria such as MRSA. In the future, it is necessary to optimize its use in combination with clinical practice to promote its wide application in the prevention and control of neonatal infections.

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