Wound healing after burns and cosmetic care of healed skin are difficult problems to solve. Clinical burn treatment technology is constantly improving, and the treatment technology for controlling wound infection has also made progress. However, residual wound care in the later stage of burns is still affected by many factors and difficult to heal, resulting in a serious impact on the beauty of the skin after wound healing. Burn patients often experience symptoms such as hypothermia and fluid loss, so it is critical for medical workers to cover the wound surface with dressings. Relevant literature reports the use of HOCL in European and American countries. Its application in wound treatment of skin infections can effectively eliminate pathogenic bacteria of skin and soft tissue infections and plays a very good role. Hypochlorous acid wound cleaning liquid dressing is formed by dissolving 0.01% pure hypochlorous acid in physiological saline. In recent years, the clinical application of PRP (platelet-rich plasma) combined with hypochlorous acid cleansing dressings in burn wound healing has shown significant efficacy. According to a study, PRP combined with hypochlorous acid cleaning dressings can effectively accelerate wound healing in burn patients, improve the patient's scar condition, and help prevent infection.
Specifically, the study retrospectively analyzed the data of 80 burn patients and found that the number of dressing changes and wound healing time of patients using PRP combined with hypochlorous acid cleaning dressings was significantly less than that of the conventional treatment group, and the VSS score was in the It was significantly reduced after treatment, indicating that the inflammatory response was effectively controlled. In addition, the patient satisfaction in the hypochlorous acid group was significantly higher than that in the conventional group, which further illustrates the advantages of combined therapy in clinical application.
PRP itself has multiple mechanisms to promote wound healing. Studies have shown that PRP can improve skin wound healing by regulating local inflammation, enhancing angiogenesis and re-epithelialization. In addition, growth factors in PRP, such as TGF-β1 and PDGF, play an important role in the wound healing process and promote cell proliferation and differentiation. These factors not only accelerate wound healing but also reduce the occurrence of inflammatory reactions.
Hypochlorous acid(HOCL,HCLO,Anolyte), as an antibacterial agent, also shows good results in wound treatment. It can effectively reduce the number of bacteria on the wound and provide a cleaner environment for wound healing. Hypochlorous acid solution combined with silver ion dressing has been proven in clinical applications to promote the growth of new capillaries and fibroblasts and accelerate the wound healing process.
PRP combined with hypochlorous acid clean dressing has shown significant efficacy in burn wound healing, not only shortening the healing time , but also improving patient satisfaction and treatment effect . This combination therapy has important promotion value in clinical practice, especially when rapid healing and reduced risk of infection are required.
The specific mechanism of action of PRP combined with hypochlorous acid cleaning dressing in burn wound healing
PRP’s mechanism of action:
Promote cell proliferation and angiogenesis: PRP contains a large number of growth factors, which can promote cell proliferation and angiogenesis, thus accelerating the wound healing process. Research shows that PRP can significantly improve burn scar pigmentation, skin texture, and reduce neuropathic pain.
Antibacterial effect: The white blood cells in PRP can chemotaxis, aggregate and activate macrophages, neutrophils, etc. through the regulation of various cytokines and biological proteins to phagocytose pathogenic microorganisms and enhance local anti-infection ability.
Inhibit inflammatory response: PRP can reduce excessive inflammatory response by inhibiting the transcription and activity of inflammatory factors, thereby providing a more stable environment for wound healing.
The mechanism of action of hypochlorous acid:
Highly effective sterilization: Hypochlorous acid has a strong and rapid antibacterial effect, and can directly penetrate microbial cells, spore walls and amoeba cysts, while destroying bacterial biofilms without interfering with the growth of wound epithelial and fibroblast cells. The sterilization efficiency of hypochlorous acid is 50 times that of hydrogen peroxide, and it has no cytotoxicity and microbial resistance.
Promote wound healing: Hypochlorous acid can not only promote wound healing in a moist environment, but also keep the healing environment moist and accelerate wound healing. In addition, hypochlorous acid can remove bacterial membranes, oxidize proteins, has a broad spectrum of antibacterial properties, does not contain antibiotics, and has no drug resistance.
High safety: Hypochlorous acid solution has no obvious cytotoxicity to human tissues and is beneficial to the migration of fibroblasts and keratinocytes, meeting the requirements for wound cleaning.
Advantages of combined application:
Synergistic effect: The combined use of PRP and hypochlorous acid can play a synergistic role in promoting rapid wound healing. PRP accelerates wound healing by promoting cell proliferation and angiogenesis, while hypochlorous acid controls infection through its highly effective bactericidal and antibacterial effects. The combination of the two can provide protection for the preparation of the "wound bed".
Reduced risk of infection: PRP is derived from the patient’s own blood, which reduces the occurrence of infection, while hypochlorous acid further reduces the risk of infection through its highly efficient bactericidal ability.
Regarding hypochlorous acid cleaning dressings, although there is no direct evidence of its use in combination with PRP, hypochlorous acid is also used as a disinfectant in the treatment of chronic wounds. For example, some studies have shown the efficacy of hypochlorous acid disinfectant combined with moist healing methods for chronic wounds.
In studies of PRP (platelet-rich plasma) combined with hypochlorous acid cleansing dressings for burn wounds, potential side effects or adverse reactions reported include:
Fever: During the treatment, one patient developed fever, but the temperature returned to normal after symptomatic treatment. This indicates that PRP treatment may cause a transient fever reaction, but it can usually be relieved with appropriate treatment.
No local redness, swelling, infection, etc.: During the use of PRP and hypochlorous acid to clean the dressing, no obvious local redness, swelling, or infection was observed, which shows that the combination of these two methods can keep the wound surface stable and clean to a certain extent.
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