Chronic rhinosinusitis (CRS) is a common inflammatory disease with a high incidence and intractable symptoms such as nasal discharge, nasal congestion, cough, and postnasal drip. However, antibiotic treatment and surgical treatment have not made significant progress in controlling patient symptoms. Therefore, various adjuvant therapies, nasal irrigation, topical steroids, nebulized inhalation, and oxadiazine antagonists are used to try to control the symptoms of chronic sinusitis.
As a new type of nasal irrigation solution, low-concentration hypochlorous acid (HOCl) has received extensive attention and research in the treatment of chronic rhinosinusitis (CRS) in recent years. According to multiple studies and evidence, low-concentration hypochlorous acid nasal irrigation has certain advantages in the treatment of CRS.
In the cytotoxicity test, Kim et al. used hypochlorous acid to treat second-generation normal human nasal epithelial (NHNE) cells for 30 minutes or 2 hours, and the cells did not show any signs of toxicity. No morphological changes were observed in NHNE treated with hypochlorous acid. It was also found that low concentrations of hypochlorous acid had no effect on secretory mucin gene expression in normal human nasal epithelial cells. Hypochlorous acid has been shown to have antibacterial, antifungal, and antiviral effects without being toxic to the nasal mucosa, thus indicating that hypochlorous acid can be effectively used for nasal irrigation.
Low-concentration hypochlorous acid solution has significant antibacterial, antiviral and antifungal effects and can effectively kill a variety of pathogens, including bacteria, fungi and viruses. Its bactericidal effect can reach more than 99% and is non-cytotoxic. This property makes HOCl excellent at clearing pathogens from the nasal cavity, thereby helping to reduce infection and inflammatory responses.
Multiple studies have shown that low-concentration hypochlorous acid nasal irrigation improves symptoms in patients with chronic sinusitis better than traditional saline irrigation. For example, research from Yonsei University in South Korea shows that HOCl nasal irrigation can significantly improve the symptoms of chronic sinusitis in children, and its improvement effect is more obvious compared with normal saline. In addition, another study also pointed out that HOCl nasal irrigation has a positive effect in local anti-infection, anti-inflammatory, reducing mucosal edema reaction, improving local immunity, and promoting epithelial regeneration.
There are many kinds of nasal irrigators. The nasal irrigator that produces low-concentration hypochlorous acid through micro-electrolysis produces low-concentration hypochlorous acid of about 3.5 ppm through micro-electrolysis of sodium chloride. Utilizing low-concentration hypochlorous acid's safe, non-toxic, high-efficiency, broad-spectrum antibacterial properties and inhibiting the expression of inflammatory factors, it can spray and flush the nasal cavity, including sinuses, to significantly relieve the symptoms of inflammation of the nasal cavity and nasal mucosa. Use hypochlorous acid to suppress
It inhibits inflammatory cytokines and significantly relieves symptoms of nasal mucosal inflammation such as edema, congestion, nasal congestion, and nasal discharge; prevents and controls diseases: Hypochlorous acid is used for its high-efficiency and broad-spectrum antibacterial and antiviral properties to treat pathogens caused by or related to pathogens. Closely related nasal conditions play a role in control and prevention. Safe, non-irritating and non-allergenic.
3.5 ppm low-concentration hypochlorous acid saline has no cytotoxicity, no irritation, no sensitization, and no drug resistance. It does not affect the barrier function of nasal epithelial cells and the clearance function of nasal cilia. It does not have any toxic or side effects when used for a long time. No additional disinfection is required. When the product generates hypochlorous acid through electrolysis, it effectively disinfects and sterilizes the spray bottle itself and the lotion in the bottle, ensuring that no lotion enters the nose.
Bacteria, prevent external bacteria from invading and causing infection, which will make nasal inflammation more serious the more you wash it. Convenient and easy to use: Each nasal wash requires only a small amount of water and 1 pack of special salt. The product is small and portable, so you can wash your nose anytime and anywhere.
using low concentration hypochlorous acid water as nasal irrigation :
Nasal irrigation with saline is a simple and cost-effective method that can help remove nasal mucus, enhance mucociliary clearance, and reduce bacteria, allergens, or fungi in the nasal cavity, thereby relieving mucosal inflammation. However, saline nasal irrigation itself lacks antibacterial activity and has limited effect in removing viscous mucus and killing bacteria. Mucin is hydrophobic and charged, so it is particularly ineffective for chronic rhinosinusitis (CRS).
Low concentration hypochlorous acid has high efficiency and broad spectrum of antibacterial, antifungal and antiviral activities. Experiments show that low concentration (<3.5ppm) hypochlorous acid can quickly kill common pathogens including drug-resistant bacteria, fungi and viruses, such as Staphylococcus aureus, Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans and human influenza A virus within 30 seconds, and the bactericidal activity basically reaches 99%. In addition, in the experiment of human influenza A virus cells, the virus was also reduced. It is non-toxic to the nasal mucosa and is a beneficial flushing solution for patients with nasal diseases.
Studies have shown that compared with saline irrigation, low-concentration hypochlorous acid nasal wash has a more significant improvement effect on the symptoms of chronic rhinosinusitis in adult patients, and it is suggested that low-concentration hypochlorous acid can be used as an adjuvant treatment for chronic rhinosinusitis (CRS); low-concentration hypochlorous acid nasal wash is a more effective adjuvant treatment for sinusitis in children compared with isotonic saline, and no adverse events have been found; nasal irrigation with low-concentration hypochlorous acid solution can relieve the symptoms of the common cold.
In summary , the low concentration of hypochlorous acid (3.5ppm) produced by micro-electrolysis of sodium chloride in a portable nasal irrigator has good antibacterial and antiviral activity and is non-cytotoxic. This concentration meets the World Health Organization's safety requirements for 5 mg/L (i.e., 5ppm) hypochlorous acid in drinking water. Therefore, compared with traditional saline rinses, low-concentration hypochlorous acid is more recommended as a nasal rinse, and this nasal irrigator is expected to produce better clinical effects.
BLUEWAV specializes in the production of medical grade hypochlorous acid solution, which is cleaner, has no residual salt, has a concentration of 50-2000ppm, has very few by-products, and consumes less raw materials. It is widely used in medical and health services, medical machinery, human body, and food disinfection.
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